The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 64: Pyrroline-5-carboxylate reductase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
8 Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q922W5 (/ISS) Q922W5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) Q96C36 (/IPI) Q96C36 (/IPI)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
5 P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
5 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
2 Q922W5 (/ISO) Q922W5 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q922W5 (/ISO) Q922W5 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
17 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(7 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
17 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(7 more)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
7 P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) Q96C36 (/IDA) Q96C36 (/IDA)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
7 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) Q96C36 (/TAS) Q96C36 (/TAS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
7 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) Q96C36 (/IMP) Q96C36 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
5 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
5 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
5 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 A0A140LG13 (/IMP) F1RDD0 (/IMP) Q503F1 (/IMP)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q922W5 (/ISO) Q922W5 (/ISO)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
2 Q922W5 (/ISO) Q922W5 (/ISO)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
17 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(7 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 A0A0S2Z5U6 (/IDA) A0A0S2Z5U6 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) Q96C36 (/IDA) Q96C36 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
7 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) Q96C36 (/TAS) Q96C36 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q922W5 (/HDA) Q922W5 (/HDA)