CATH / Gene3D v4.3

151 million protein domains classified into 5,841 superfamilies

CATH annotations for the 21 model organisms predicted by AlphaFold (v2) are available to download (doi:10.1038/s42003-023-04488-9). Core classification files for the latest version of CATH-Plus (v4.3) are available to download. Daily updates of our very latest classifications are also available.

3D Structure

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Protein Evolution

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Protein Function

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Conserved Sites

Look at protein sites that are highly conserved and implicated in function

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Find out how CATH is created and maintained, how to link to CATH and more

What is CATH-Gene3D?

CATH is a classification of protein structures downloaded from the Protein Data Bank. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor.

Gene3D uses the information in CATH to predict the locations of structural domains on millions of protein sequences available in public databases. This allows us to include additional annotations to the CATH-Gene3D database such as functional information and active site residues.

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Latest Release Statistics Info

CATH-Plus 4.3.0 CATH (daily snapshot)
PDB Release 01-07-2019
Domains 500238 536613
Superfamilies 5481 6631
Annotated PDBs 150885 190714

Gene3D v21
Protein Sequences82,665,384
CATH Domain Predictions151,013,797

Citing this resource

If you find the information in this resource useful, please consider using the following citations:

CATH: increased structural coverage of functional space.
Sillitoe I, Bordin N, Dawson N, Waman VP, Ashford P, Scholes HM, Pang CSM, Woodridge L, Rauer C, Sen N, Abbasian M, Le Cornu S, Lam SD, Berka K, Varekova IH, Svobodova R, Lees J, Orengo CA.
Nucleic Acids Res. 2021 Jan
CATH 2024: CATH-AlphaFlow Doubles the Number of Structures in CATH and Reveals Nearly 200 New Folds
Waman VP, Bordin N, Alcraft R, Vickerstaff R, Rauer C, Chan Q, Sillitoe I, Yamamori H, Orengo C.
J Mol Biol.
CATH--a hierarchic classification of protein domain structures.
Orengo CA, Michie AD, Jones S, Jones DT, Swindells MB, Thornton JM.
Gene3D: Extensive prediction of globular domains in proteins.
Lewis TE, Sillitoe I, Dawson N, Lam SD, Clarke T, Orengo CA, Lees JG.
Nucleic Acids Res. 2018 Jan


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