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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Malate dehydrogenase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Malate dehydrogenase. [EC: 1.1.1.37]
(S)-malate + NAD(+) = oxaloacetate + NADH.
  • Also oxidizes some other 2-hydroxydicarboxylic acids.
 16879 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8 A0A015QKM8
(16869 more...)
L-lactate dehydrogenase. [EC: 1.1.1.27]
(S)-lactate + NAD(+) = pyruvate + NADH.
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
 10338 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0 A0A023P5T0
(10328 more...)