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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 121: Prostaglandin reductase 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
15-oxoprostaglandin 13-reductase. [EC: 1.3.1.48]
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
  • Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
  • The enzyme from placenta is specific for NAD(+).
 26 H2Q8K7 H2Q8K7 H2Q8K7 L8IN04 L8IN04 P97584 Q14914 Q14AZ9 Q14AZ9 Q24K16
(16 more...)
2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
 12 A0A178U6Z5 A0A178U6Z5 A0A178UC71 A0A178UC71 P97584 Q14914 Q29073 Q39172 Q39172 Q39173
(2 more...)
(+)-pulegone reductase. [EC: 1.3.1.81]
(1) (-)-menthone + NADP(+) = (+)-pulegone + NADPH. (2) (+)-isomenthone + NADP(+) = (+)-pulegone + NADPH.
  • NADH cannot replace NADPH as reductant.
  • The Delta(8,9)-double bond of (+)-cis-isopulegone and the Delta(1,2)- double bond of (+-)-piperitone are not substrates.
  • The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyze the reverse reaction.
 1 Q6WAU0