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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1083: Bile acid 7-dehydroxylase 1/3

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-alpha-hydroxybile acid CoA 3-dehydrogenase. [EC: 1.1.1.395]
A 3-alpha-hydroxy bile acid CoA ester + NAD(+) = a 3-oxo bile acid CoA ester + NADH.
  • This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation.
  • The enzyme has very little activity with unconjugated bile acid substrates.
  • It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA.
  • Formerly EC 1.17.98.1.
 2 P07914 P19337