CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Ketol-acid reductoisomerase (NADP(+))

Enzyme Information

1.1.1.86
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt Q2FWK4
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.

UniProtKB Entries (1)

Q2FWK4
ILVC_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
Ketol-acid reductoisomerase (NADP(+))

PDB Structure

PDB 5W3K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.
Patel, K.M., Teran, D., Zheng, S., Kandale, A., Garcia, M., Lv, Y., Schembri, M.A., McGeary, R.P., Schenk, G., Guddat, L.W.
Chemistry
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