CATH Domain 5oohA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	flavin reductase (NADPH)

Enzyme Information

1.5.1.30	Flavin reductase (NADPH). based on mapping to UniProt P30043 Reduced riboflavin + NADP(+) = riboflavin + NADPH. -!- The enzyme from Entamoeba histolytica reduces riboflavin and galactoflavin, and, more slowly, FMN and FAD. -!- NADH is oxidized more slowly than NADPH. -!- Formerly EC 1.6.8.2.
1.3.1.24	Biliverdin reductase. based on mapping to UniProt P30043 Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H.

UniProtKB Entries (1)

BLVRB_HUMAN

Homo sapiens

Flavin reductase (NADPH)

PDB Structure

PDB	5OOH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	In silicoand crystallographic studies identify key structural features of biliverdin IX beta reductase inhibitors having nanomolar potency. Nesbitt, N.M., Zheng, X., Li, Z., Manso, J.A., Yen, W.Y., Malone, L.E., Ripoll-Rozada, J., Pereira, P.J.B., Mantle, T.J., Wang, J., Bahou, W.F. J. Biol. Chem.