CATH Domain 4bvaB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	ketimine reductase mu-crystallin

Enzyme Information

1.5.1.25

Thiomorpholine-carboxylate dehydrogenase.

based on mapping to UniProt O54983

Thiomorpholine 3-carboxylate + NAD(P)(+) = 3,4-dehydro-thiomorpholine-3- carboxylate + NAD(P)H.

-!- The product is the cyclic imine of the 2-oxoacid corresponding to S-(2-aminoethyl)cysteine. -!- In the reverse direction, a number of other cyclic unsaturated compounds can act as substrates, more slowly.

UniProtKB Entries (1)

O54983

CRYM_MOUSE

Mus musculus

Ketimine reductase mu-crystallin

PDB Structure

PDB	4BVA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Mouse Mu-Crystallin Complexed with Nadph and the T3 Thyroid Hormone Borel, F., Hachi, I., Palencia, A., Gaillard, M.C., Ferrer, J.L. FEBS J.