CATH Domain 3wjaB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Malic enzyme

Enzyme Information

1.1.1.40

Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).

based on mapping to UniProt P48163

(1) (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH. (2) Oxaloacetate = pyruvate + CO(2).

-!- The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.

UniProtKB Entries (1)

P48163

MAOX_HUMAN

Homo sapiens

NADP-dependent malic enzyme

PDB Structure

PDB	3WJA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural characteristics of the nonallosteric human cytosolic malic enzyme Hsieh, J.Y., Li, S.-Y., Chen, M.-C., Yang, P.-C., Chen, H.-Y., Chan, N.-L., Liu, J.-H., Hung, H.-C. Biochim.Biophys.Acta