CATH Domain 3rqsB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Enzyme Information

1.1.1.35

3-hydroxyacyl-CoA dehydrogenase.

based on mapping to UniProt Q16836

(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.

-!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

Q16836

HCDH_HUMAN

Homo sapiens

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

PDB Structure

PDB	3RQS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Northeast Structural Genomics Consortium Target HR487 Kuzin, A., Su, M., Seetharaman, J., Patel, P., Xiao, R., Ciccosanti, C., Shastry, R., Everett, J.K., Nair, R., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F. To be published