CATH Domain 3o4rD00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Short-chain dehydrogenase reductase

Enzyme Information

1.1.1.184

Carbonyl reductase (NADPH).

based on mapping to UniProt Q9BTZ2

R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.

-!- Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol. -!- Si-specific with respect to NADPH (cf. EC 1.1.1.2).

UniProtKB Entries (1)

Q9BTZ2

DHRS4_HUMAN

Homo sapiens

Dehydrogenase/reductase SDR family member 4

PDB Structure

PDB	3O4R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Dehydrogenase/Reductase (SDR family) member 4 (DHRS4) Ugochukwu, E., Bhatia, C., Krojer, T., Vollmar, M., Yue, W.W., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U. To be Published