CATH Domain 3gvpD02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Adenosylhomocysteinase

Enzyme Information

3.3.1.1

Adenosylhomocysteinase.

based on mapping to UniProt Q96HN2

S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

Q96HN2

SAHH3_HUMAN

Homo sapiens

Adenosylhomocysteinase 3

PDB Structure

PDB	3GVP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure Siponen, M.I., Wisniewska, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Moche, M., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Schutz, P., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Schueler, H. To be Published