CATH Domain 2y05D02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Prostaglandin reductase 2

Enzyme Information

1.3.1.48	15-oxoprostaglandin 13-reductase. based on mapping to UniProt Q14914 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H. -!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).
1.3.1.74	2-alkenal reductase (NAD(P)(+)). based on mapping to UniProt Q14914 A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H. -!- Highly specific for 4-hydroxynon-2-enal and non-2-enal. -!- Alk-2-enals of shorter chain have lower affinities. -!- Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. -!- Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. -!- Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
1.3.1.-	With NAD(+) or NADP(+) as acceptor. based on mapping to UniProt Q14914

UniProtKB Entries (1)

PTGR1_HUMAN

Homo sapiens

Prostaglandin reductase 1

PDB Structure

PDB	2Y05
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Leukotriene B4 12-Hydroxydehydrogenase in Complex with Nadp and Raloxifene Yue, W.W., Shafqat, N., Krojer, T., Pike, A.C.W., von Delft, F., Sethi, R., Savitsky, P., Johansson, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U. To be Published