CATH Domain 2o23B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	3-hydroxyacyl-CoA dehydrogenase type-2

Enzyme Information

1.1.1.178	3-hydroxy-2-methylbutyryl-CoA dehydrogenase. based on mapping to UniProt Q99714 (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH. -!- Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
1.1.1.51	3(or 17)-beta-hydroxysteroid dehydrogenase. based on mapping to UniProt Q99714 Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H. -!- Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
1.1.1.35	3-hydroxyacyl-CoA dehydrogenase. based on mapping to UniProt Q99714 (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. -!- Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate. -!- Some enzymes act, more slowly, with NADP(+). -!- Broad specificity to acyl chain-length (cf. EC 1.1.1.211).

UniProtKB Entries (1)

HCD2_HUMAN

Homo sapiens

3-hydroxyacyl-CoA dehydrogenase type-2

PDB Structure

PDB	2O23
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A KAVANAGH, K.L., SHAFQAT, N., SCHOLER, K., DEBRECZENI, J., ZSCHOCKE, J., von Delft, F., WEIGELT, J., ARROWSMITH, C., SUNDSTROM, M., EDWARDS, A., OPPERMANN, U. To be Published