CATH Domain 2cdcD02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Glucose 1-dehydrogenase

Enzyme Information

1.1.1.120	Galactose 1-dehydrogenase (NADP(+)). based on mapping to UniProt O93715 D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH. -!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.
1.1.1.48	D-galactose 1-dehydrogenase. based on mapping to UniProt O93715 D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH. -!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
1.1.1.359	Aldose 1-dehydrogenase (NAD(P)(+)). based on mapping to UniProt O93715 An aldopyranose + NAD(P)(+) = an aldono-1,5-lactone + NAD(P)H. -!- The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity toward aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD(+) and NADP(+) with similar catalytic efficiency. -!- It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
1.1.1.47	Glucose 1-dehydrogenase (NAD(P)(+)). based on mapping to UniProt O93715 D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H. -!- This enzyme has similar activity with either NAD(+) or NADP(+). -!- Cf. EC 1.1.1.118 and EC 1.1.1.119.

UniProtKB Entries (1)

GLCDH_SACSO

Saccharolobus solfataricus

Glucose 1-dehydrogenase

PDB Structure

PDB	2CDC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. Milburn, C.C., Lamble, H.J., Theodossis, A., Bull, S.D., Hough, D.W., Danson, M.J., Taylor, G.L. J. Biol. Chem.