CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Inositol-3-phosphate synthase 1 |
Enzyme Information
| 5.5.1.4 |
Inositol-3-phosphate synthase.
based on mapping to UniProt P11986
D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
-!- The NAD(+) dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1; finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.
|
UniProtKB Entries (1)
| P11986 |
INO1_YEAST
Saccharomyces cerevisiae S288C
Inositol-3-phosphate synthase
|
PDB Structure
| PDB | 1RM0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of the 1L-myo-inositol-1-phosphate synthase-NAD+-2-deoxy-D-glucitol 6-(E)-vinylhomophosphonate complex demands a revision of the enzyme mechanism.
J.Biol.Chem.
|
