CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 6-phosphogluconate dehydrogenase, decarboxylating |
Enzyme Information
| 1.1.1.44 |
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
based on mapping to UniProt P31072
6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.
|
UniProtKB Entries (1)
| P31072 |
6PGD_TRYBB
Trypanosoma brucei brucei
6-phosphogluconate dehydrogenase, decarboxylating
|
PDB Structure
| PDB | 1PGJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A 2.8 A resolution structure of 6-phosphogluconate dehydrogenase from the protozoan parasite Trypanosoma brucei: comparison with the sheep enzyme accounts for differences in activity with coenzyme and substrate analogues.
J.Mol.Biol.
|
