CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Sorbitol dehydrogenase |
Enzyme Information
| 1.1.1.14 |
L-iditol 2-dehydrogenase.
based on mapping to UniProt Q59787
L-iditol + NAD(+) = L-sorbose + NADH.
-!- This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. -!- It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. -!- Enzymes from different organisms or tissues display different substrate specificity. -!- The enzyme is specific to NAD(+) and can not use NADP(+).
|
| 1.1.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt Q59787
|
| 1.1.1.16 |
Galactitol 2-dehydrogenase.
based on mapping to UniProt Q59787
Galactitol + NAD(+) = D-tagatose + NADH.
-!- Also converts other alditols containing an L-threo-configuration adjacent to a primary alcohol group into the corresponding sugars. -!- The enzyme from Agrobacterium rubrum C58 is part of D-altritol and galactitol degradation pathways.
|
UniProtKB Entries (1)
| Q59787 |
SDH_RHOSH
Rhodobacter sphaeroides
Sorbitol dehydrogenase
|
PDB Structure
| PDB | 1K2W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution.
Acta Crystallogr.,Sect.D
|
