CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 7-alpha-hydroxysteroid dehydrogenase |
Enzyme Information
| 1.1.1.159 |
7-alpha-hydroxysteroid dehydrogenase.
based on mapping to UniProt P0AET8
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH.
-!- Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms. -!- The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+).
|
UniProtKB Entries (1)
| P0AET8 |
HDHA_ECOLI
Escherichia coli K-12
7-alpha-hydroxysteroid dehydrogenase
|
PDB Structure
| PDB | 1FMC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
Biochemistry
|
